How does the AccordQuick system revolutionize on-site nucleic acid testing in veterinary settings with its integrated microfluidic technology?
Publish Time: 2025-11-19
In the context of animal disease prevention and control increasingly emphasizing "early detection, rapid response, and accurate diagnosis," traditional laboratory testing, due to its cumbersome processes, long cycles, and reliance on specialized personnel, struggles to meet the immediate diagnostic needs of frontline scenarios such as farms, veterinary hospitals, and border quarantine. The AccordQuick series of fully automated thin-film microfluidic nucleic acid testing systems addresses this need, integrating nucleic acid extraction, quantitative PCR amplification, and result interpretation into a single, closed operation. With its fully automated "sample in, result out" process, high sensitivity, and portable design, it completely redefines the timeliness and accessibility of veterinary diagnosis.
The core superiority of the AccordQuick system is primarily reflected in its innovative thin-film microfluidic chip architecture. This chip utilizes a multi-layered polymer film thermoforming process, incorporating micron-level flow channels, reaction chambers, and valve structures. Through precise fluid control, it achieves fully automated nucleic acid extraction, including sample lysis, magnetic bead capture, washing purification, and elution. The entire process requires no centrifugation, pipetting, or opening the instrument, effectively avoiding cross-contamination and aerosol risks. Extracted nucleic acids are directly introduced into the pre-prepared lyophilized reagent qPCR reaction zone, completing 40–45 cycles of fluorescence amplification within the same chip. Detection sensitivity reaches 10–100 copies/μL, demonstrating excellent specificity and reproducibility against various important pathogens, including canine parvovirus, feline panleukopenia virus, avian influenza H5N1, and African swine fever virus.
The extremely simple operation greatly lowers the barrier to entry. Users only need to add blood, swabs, or tissue homogenate samples to a dedicated sampling tube, insert it into the instrument slot, and click "Start" for fully automatic operation. The system has a built-in intelligent temperature control module with a heating/cooling rate of up to 5℃/second, completing the entire process from sample to result within 45 minutes. A 7-inch touchscreen displays the amplification curve and Ct value in real time and automatically interprets "positive/negative/invalid," eliminating the need for manual interpretation. The entire device is smaller than an A4 sheet of paper and weighs less than 5 kg. It supports vehicle power or battery power, making it suitable for ranch inspections, mobile clinics, and even emergency field scenarios.
Data management and scalability enhance clinical value. Test results can be exported as PDF or CSV via Wi-Fi or USB, seamlessly integrating with veterinary electronic medical record systems. The device supports multi-channel parallel testing (such as quadruple-chip detection), allowing screening for multiple pathogens in a single run. Reagents are freeze-dried, ensuring stable storage at room temperature for over 6 months, eliminating the hassle of cold chain transportation. All consumables are single-use and sealed, complying with Biosafety Level 2 (BSL-2) operating procedures to guarantee operator safety.
In practical applications, the accordquick system has demonstrated significant public health and economic value. Large-scale pig farms can quickly identify the source of ASFV infection in the early stages of an outbreak, avoiding mass culling; veterinary hospitals can diagnose feline infectious peritonitis (FIP) on the day of visit, initiating timely treatment; customs quarantine personnel can conduct initial screening for avian influenza at ports of entry, blocking cross-border transmission chains. This "pre-detection, pre-decision-making" model significantly shortens the response window, reducing the risk of disease spread and economic losses.
Ultimately, the value of the AccordQuick system lies not only in "completing the test," but also in its ability to build a precise technological defense line for disease prevention in the fields, leveraging the precision of microfluidics, the intelligence of automation, and portability. When a sick cow is promptly isolated, or a cat receives accurate treatment, this small device silently safeguards animal health and industry safety. In today's world where the "One Health" concept is deeply ingrained, AccordQuick, with its comprehensive advantages of speed, accuracy, and ease of use, continues to drive veterinary diagnostics from the laboratory to the field, from lagging to forward-looking.
